Air pollution, EGFR mutation, and cancer initiation.

Si-Chong Han,Gui-Zhen Wang,Guang-Biao Zhou

Cell reports. Medicine（2023）

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摘要

Swanton et al.1 find that PM2.5 exposure is associated with EGFR/KRAS-driven lung cancer incidence. PM2.5 increases EGFR pre-mutated alveolar type II cell progenitor function and tumorigenic activity through interstitial macrophage-secreted IL-1β, providing potential prevention approaches to inhibit cancer initiation.

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egfr mutation,air pollution,cancer initiation

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