Local T cell infiltrates are predominantly associated with corneal allograft rejection.

Justyna Sakowska,Paulina Glasner,Anna Dukat-Mazurek,Anna Rydz,Maciej Zieliński, Irena Pellowska,Wojciech Biernat,Leopold Glasner,Katarzyna Michalska-Małecka,Piotr Trzonkowski

Transplant immunology（2023）

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摘要

PCTXs and especially RCTXs are rejected mainly by local T cells. The accumulation of effector CD4+ and CD8+ T cells, as well as CD4+ and CD8+ Tm cells is associated with the final rejection. Furthermore, local CD4+ and CD8+ Tregs expressing Foxp3 and Helios are probably insufficient to impose the acceptance of CTX.

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