A single, oral dose of the TLR7 agonist JNJ-64794964 induces transcriptomic and phenotypic changes in peripheral immune cells in healthy adults.

Wim Pierson,Marianne Tuefferd,Florence Herschke,Leen Slaets,Marjolein Crabbe,Dorien Verstappen,Steffi De Pelsmaeker,Ian Strickland,Edward J Gane,Christian Schwabe,Yingjie Zhang,Peter Meerts,Joris Vandenbossche,Pieter Van Remoortere,Inge Verbrugge,An De Creus

Antiviral therapy（2023）

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摘要

JNJ-4964 administration led to changes in transcriptional profiles and immune cell activation phenotype, particularly for NK cells and B cells. Together, these changes could represent a set of biomarkers for the characterization of the immune response in CHB patients receiving TLR7 agonists.

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关键词

Chronic hepatitis B, TLR7 agonist, JNJ-4964, transcriptomics, immune cells

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