CD4 + T cell counts and soluble programmed death-1 at baseline correlated with hepatitis B surface antigen decline in HIV/HBV coinfection during combined antiretroviral therapy.

Xiaodi Li,Ling Xu,Lianfeng Lu,Xiaosheng Liu,Yang Yang,Yuanni Wu,Yang Han,Xiaoxia Li,Yanling Li,Xiaojing Song,Wei Cao,Taisheng Li

Frontiers in cellular and infection microbiology（2023）

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摘要

Lower CD4 T cells, sPD-1, and immune activation were related to a rapid HBsAg decline in patients with HIV/HBV-coinfection after the initiation of cART. These findings imply that immune disorders induced by HIV infection may disrupt immune tolerance to HBV, leading to a faster decline in HBsAg levels during coinfection.

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antiretroviral therapy,hiv/hbv coinfection,hepatitis,surface antigen

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