White matter microstructural metrics are sensitively associated with clinical staging in Alzheimer's disease.

Yisu Yang,Kurt Schilling,Niranjana Shashikumar,Varuna Jasodanand,Elizabeth E Moore,Kimberly R Pechman,Murat Bilgel,Lori L Beason-Held,Yang An,Andrea Shafer,Shannon L Risacher,Bennett A Landman,Angela L Jefferson,Andrew J Saykin,Susan M Resnick,Timothy J Hohman,Derek B Archer

Alzheimer's & dementia (Amsterdam, Netherlands)（2023）

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摘要

successfully harmonized large-scale diffusion magnetic resonance imaging (dMRI) metrics.Conventional dMRI metrics were globally sensitive to diagnostic status.Free-water (FW) correction mitigated intracellular associations with diagnostic status.The FW metric itself was globally sensitive to diagnostic status. Multivariate conventional and FW-corrected models may provide complementary information.

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关键词

alzheimer disease,white matter,microstructural metrics

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