Elevated nuclear TDP-43 induces constitutive exon skipping.

Rogger P Carmen-Orozco,William Tsao,Yingzhi Ye,Irika R Sinha,Koping Chang,Vickie Trinh, William Chung, Kyra Bowden,Juan C Troncoso,Seth Blackshaw,Lindsey R Hayes,Shuying Sun,Philip C Wong,Jonathan P Ling

bioRxiv : the preprint server for biology（2023）

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摘要

Cytoplasmic inclusions and loss of nuclear TDP-43 are key pathological features found in several neurodegenerative disorders, suggesting both gain- and loss-of-function mechanisms of disease. To study gain-of-function, TDP-43 overexpression has been used to generate in vitroin vivo

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