TCR T cells overexpressing c-Jun have better functionality with improved tumor infiltration and persistence in hepatocellular carcinoma.

Mohamed S Hussein,Qi Li,Rui Mao,Yibing Peng,Yukai He

Frontiers in immunology（2023）

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摘要

c-Jun overexpression can enhance the expansion, function, and persistence of the A2/AFP TCR engineered T cells. The c-Jun gene co-delivery has the potential to enhance the antitumor efficacy of AFP specific TCR T cells when treating patients with HCC.

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关键词

TCR T cells, T cell engineering, adoptive cell therapy, hepatocellular carcinoma, tumor immunotherapy

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