GABAergic Effects of Etifoxine and Alprazolam Assessed by Double Pulse TMS.

Marco Riebel,Benedikt von Pappenheim,Carolina Kanig,Caroline Nothdurfter,Thomas C Wetter,Rainer Rupprecht,Jens Schwarzbach

Pharmacopsychiatry（2023）

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摘要

This study indicated a favorable side effect profile of etifoxine in healthy volunteers. Moreover, it revealed differential GABA-related effects on neuromuscular function by means of TMS. The side effects and TMS profile of etifoxine are compatible with the involvement of neurosteroidogenesis and a predominant α3 subunit modulation compared to alprazolam.

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alprazolam,etifoxine,tms

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