Transcriptomic changes in liver transplant recipients with non-alcoholic steatohepatitis indicate dysregulation of wound healing.

Diogo Pellegrina, Khairunnadiya Prayitno,Amirhossein Azhie,Elisa Pasini,Cristina Baciu,Sandra Fischer,Jüri Reimand,Mamatha Bhat

Frontiers in endocrinology（2023）

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摘要

Beyond altered lipid metabolism, dysregulation of wound healing and tissue repair mechanisms may contribute to the accelerated development of fibrosis associated with PT-NASH. This presents an attractive therapeutic avenue to explore for PT-NASH to optimize the benefit and survival of the graft.

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liver transplantation, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, disease pathogenesis, fibrosis, wound healing, transcriptomics (RNA-seq), computational biology & bioinformatics

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