AadT, a new weapon in Acinetobacter's fight against antibiotics.

Genes encoding a novel multidrug efflux pump, AadT, from the Drug:H antiporter 2 family, were discovered in multidrug resistance plasmids. Here, we profiled the antimicrobial resistance potential, and examined the distribution of these genes. homologs were found in many and other Gram-negative species and were typically adjacent to novel variants of ), which encodes a major tripartite efflux pump in . The AadT pump decreased bacterial susceptibility to at least eight diverse antimicrobials, including antibiotics (erythromycin and tetracycline), biocides (chlorhexidine), and dyes (ethidium bromide and DAPI) and was able to mediate ethidium transport. These results show that AadT is a multidrug efflux pump in the resistance arsenal and may cooperate with variants of AdeAB(C).