Post-translational Modifications by Acyl Groups Regulate FEN1's Activities and Play Essential Roles in Cell Proliferation and DNA Repair.

Yue Xiao, Mingyu Yin,Yiyi Wang,Rongyi Shi,Shuyu Mao,Yuejin Hua,Hong Xu

Protein and peptide letters（2023）

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摘要

We have veri-fied acyl groups could modify Lys125, Lys252 and Lys254 of FEN1. Acyl-ation level of these three is important for enzyme activity, cell proliferation and DNA damage response, thus contributing to genome stability.

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