Promoter methylation and enhanced SKP2 are associated with the downregulation of CDKN1C in cervical squamous cell carcinoma.

Anirban Roychowdhury,Debolina Pal,Mukta Basu,Sudip Samadder,Ranajit Mondal,Anup Roy,Susanta Roychoudhury,Chinmay Kumar Panda

Cellular signalling（2023）

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摘要

Collectively, CDKN1C was down-regulated due to the synergistic effect of promoter hyper-methylation and SKP2 over-expression in CSCC tumors, paving the way for further studies of its role in the pathogenesis of the disease.

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promoter methylation,carcinoma,cdkn1c,skp2

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