The changing landscape of pediatric histiocytoses: Birth, life, and transdifferentiation of pediatric histiocytes
Seminars in diagnostic pathology(2023)
Abstract
Histiocytic neoplasms in the children are very rare, and histiocytoses can occur in the perinatal period. The presumed origins and presentation of specific histiocytoses in the pediatric age group are described. Common and newly described histiocytoses are presented including Langerhans cell histiocytosis, Rosai-Dorfman disease, histiocytic sarcoma, ALK positive histiocytosis, and hemophagocytic lymphohistiocytosis. Molecular findings common to pediatric histiocytoses are also discussed.
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Key words
Histiocytoses,Langerhans histiocytoses,Transdifferentiation,Rosai-Dorfman disease,Histiocytic sarcoma,ALK positive histiocytosis,Hemophagocytic lymphohistiocytosis,Myeloid sarcoma
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