Additional boosting to the RV144 vaccine regimen increased Fc-mediated effector functions magnitude but not durability.

Zhanna Shubin,Sherry Stanfield-Oakley, Jiraporn Puangkaew,Punnee Pitisutthithum,Sorachai Nitayaphan,Sanjay Gurunathan,Faruk Sinangil,Suwat Chariyalertsak,Nittaya Phanuphak,Julie A Ake,Robert J O'connell,Sandhya Vasan,Siriwat Akapirat,Michael A Eller,Guido Ferrari,Dominic Paquin-Proulx

AIDS (London, England)（2023）

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摘要

Additional boosting of RV144 improved the magnitude but not the durability of some Fc mediated effector functions that were associated with vaccine efficacy, with trogocytosis being the most durable.

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关键词

antibody-dependent cellular cytotoxicity, antibody-dependent cellular phagocytosis, antibody-dependent complement deposition, antibody-dependent neutrophil phagocytosis, HIV vaccine, trogocytosis

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