Insights into the regulation of glomerular filtration rate by the Keap1-Nrf2 pathway.

Kengo Kidokoro,Hiroyuki Kadoya,David Z I Cherney,Megumi Kondo,Yoshihisa Wada,Reina Umeno,Seiji Kishi,Hajime Nagasu,Kojiro Nagai,Takafumi Suzuki,Tamaki Sasaki,Masayuki Yamamoto,Yashpal S Kanwar,Naoki Kashihara

Kidney360（2023）

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摘要

In conclusion, the Keap1-Nrf2 pathway regulates GFR through changes in ultrafiltration by modulating redox-sensitive intracellular calcium signaling and cellular contractility, mediated through TRPC activity, in glomerular cells, in particular the podocytes.

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