The Ndc80-Cdt1-Ska1 Complex is a Central Processive Kinetochore–microtubule Coupling Unit
The journal of cell biology/The Journal of cell biology(2023)
摘要
The mechanism of how mitotic kinetochores accomplish robust, long-distance coupling with spindle microtubule plus-ends during metaphase and anaphase is unknown. This work demonstrates that the replication licensing protein Cdt1 synergizes with kinetochore Ndc80 and the Ska1 complexes to form a tripartite Ndc80-Cdt1-Ska1 complex that processively tracks the plus-ends of dynamic microtubules.
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