Hypomethylation and overexpression of Th17-associated genes is a hallmark of intestinal CD4+ lymphocytes in Crohn's disease.

Zhifu Sun,Manuel B Braga-Neto,Yuning Xiong, Adytia V Bhagwate,Hunter Gibbons,Mary Sagstetter,Feda H Hamdan,Saurabh Baheti,Jessica Friton,Asha Nair,Zhenqing Ye,William A Faubion

Journal of Crohn's & colitis（2023）

引用 0|浏览2

暂无评分

摘要

The methylome of CD patients demonstrate an overall dominant hypermethylation yet hypomethylation is more concentrated in proinflammatory pathways, including Th17 differentiation. Hypomethylation of Th17-related genes associated with areas of open chromatin and CTCF binding sites constitutes a hallmark of CD-associated intestinal CD4 + cells.

查看译文

关键词

intestinal cd4+,crohns,lymphocytes

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要