Ongoing HIV-1 evolution and reservoir reseeding in two elite controllers with genetically diverse peripheral proviral quasispecies.

Suwellen Sardinha Dias de Azevedo,Fernanda Heloise Côrtes,Larissa M Villela,Brenda Hoagland,Beatriz Grinsztejn,Valdilea Gonçalvez Veloso,Mariza G Morgado,Gonzalo Bello

Memorias do Instituto Oswaldo Cruz（2023）

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摘要

These findings support that the high intra-host HIV-1 diversity of some EC resulted from long-term persistence of archival proviruses combined with the continuous reservoir's reseeding and low, but measurable, viral evolution despite undetectable viremia.

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关键词

proviral reservoir, elite controllers, HIV-1, viral diversity, viral evolution

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