ANG2 Blockade Diminishes Proangiogenic Cerebrovascular Defects Associated With Models of Hereditary Hemorrhagic Telangiectasia.

Xingyan Zhou, Jenna C Pucel,Aya Nomura-Kitabayashi,Pallavi Chandakkar,Adella P Guidroz,Nikita L Jhangiani,Duran Bao,Jia Fan,Helen M Arthur,Christoph Ullmer,Christian Klein,Philippe Marambaud,Stryder M Meadows

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

Elevation of ANG2 in the brain vasculature is a shared trait among the mouse models of the common forms of HHT. Inhibition of ANG2 activity can significantly limit or prevent brain arteriovenous malformation formation and blood vessel enlargement in HHT mice. Thus, ANG2-targeted therapies may represent a compelling approach to treat arteriovenous malformations and vascular pathologies related to all forms of HHT.

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关键词

angiogenesis, angiopoietin, arteriovenous malformations, brain, endothelial

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