Decreased SIRT1 mRNA expression in peripheral blood mononuclear cells from patients with neuromyelitis optica spectrum disorders.

Lu Zhang,Yumei Xue,Congcong Yuan,Xiaochen Du,Xuan Wang,Li Guo,Bin Li

Acta neurologica Belgica（2023）

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摘要

Our study indicated that SIRT1 mRNA expression was downregulated in the PBMCs of patients with acute-phase NMOSD, and its level was correlated with the clinical parameters of the patients, suggesting a potential role of SIRT1 in NMOSD.

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关键词

Neuromyelitis optica spectrum disorders, Sirtuin 1, mRNA, Peripheral blood mononuclear cells, Acetylation

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