The therapeutic role and potential mechanism of EGCG in obesity-related precocious puberty as determined by integrated metabolomics and network pharmacology.

Qiuyun Gu,Lina Xia, Qiuju Du,Ying Shao,Jieyi He,Peiying Wu,Lingwei Liang,Xiuhua Shen

Frontiers in endocrinology（2023）

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摘要

EGCG may contribute to preventing obesity-related precocious puberty through targets such as AKT1, EGFR, ESR1, STAT3, IGF1, and MAPK1 and multiple signaling pathways, including the estrogen, PI3K-Akt, MAPK, and Jak-STAT pathways. This study provided a theoretical foundation for future research.

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关键词

precocious puberty,egcg,integrated metabolomics,obesity-related

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