Exploration of the impact of multimode thermal therapy versus radiofrequency ablation on CD8 + T effector cells of liver malignancies based on single cell transcriptomics.

Ying Wang,Guang-Zhi Wang,Chao Chen,Hao-Zhe Huang,Yao-Hui Wang,Xin-Hong He, Lisa X Xu,Li-Chao Xu,Wen-Tao Li

Frontiers in immunology（2023）

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摘要

This study confirmed that MTT could more effectively activate peripheral CD8 Teff cells in patients compared with RFA and promote the effector function, thus resulting in a better prognosis. These results provide a theoretical basis for the clinical application of MTT therapy.

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关键词

CD8(+) effector T cells, liver cancer, radiofrequency ablation, multi-mode thermal therapy, single-cell RNA sequencing

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