Histone methyltransferase enzyme enhancer of zeste homolog 2 counteracts ischemic brain injury via H3K27me3-mediated regulation of PI3K/AKT/mTOR signaling pathway.
Environmental toxicology（2023）
Abstract
Collectively, our results demonstrate that EZH2 inhibition exerts a protective effect against ischemic brain injury by modulating the H3K27me3/PI3K/AKT/mTOR signaling pathway. The results provide novel insights into potential therapeutic mechanisms for stroke treatment.
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Key words
AKT, cerebral ischemia-reperfusion injury, EZH2, histone methylation, MCAO, mTOR, OGD, R, PI3K
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