Pharmacodynamics Monitoring of Emicizumab in Patients with Hemophilia A.

Debora Bertaggia Calderara,Rita Marchi Cappelletti,Ana Patricia Batista Mesquita Sauvage,Stéphane Durual,Francisco J Gomez,Maxime G Zermatten,Alessandro Aliotta,Alessandro Casini,Lorenzo Alberio

Thrombosis and haemostasis（2023）

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摘要

Our study enriches the knowledge on the use of GCA to monitor non-factor replacement therapy, indicating that TG and FCF could act as direct markers of emicizumab biological activity. GCA allow to capture and visualize the individually variable response to emicizumab, leading a step forward to the personalization of patient treatment.

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关键词

emicizumab pharmacodynamics, global coagulation assays, non-factor replacement, thrombin generation, fibrin clot formation, fibrin clot structure

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