Outcomes of HSV-1 encephalitis infection in glioblastoma: An integrated systematic analysis.

Mynor J Mendez Valdez,Enoch Kim,Shovan Bhatia,Ali G Saad,Charif Sidani,Lekhaj Daggubati, Jay Chandar,Deepa Seetharam,Jelisah Desgraves,Shreya Ingle,Evan Luther,Michael Ivan,Ricardo Komotar,Ashish H Shah

Microbial pathogenesis（2023）

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摘要

Superimposed HSE in GBM may contribute to a significant reduction in OS compared to uninfected controls, potentially activating proto-oncogenes during active infection and latency. Preoperative HSE may induce an antiviral immune response, which may serve as a positive prognostic factor. Prompt antiviral treatment upon co-occurrence is necessary.

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glioblastoma

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