Characterization and evaluation of gene fusions as a measure of genetic instability and disease prognosis in prostate cancer.

Carolin Schimmelpfennig,Michael Rade,Susanne Füssel,Dennis Löffler,Conny Blumert,Catharina Bertram,Angelika Borkowetz,Dominik J Otto,Sven-Holger Puppel,Pia Hönscheid,Ulrich Sommer,Gustavo B Baretton,Ulrike Köhl,Manfred Wirth,Christian Thomas,Friedemann Horn,Markus Kreuz,Kristin Reiche

BMC cancer（2023）

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摘要

Our gene fusion characterization workflow revealed two potential novel fusions specific for PCa. We found evidence that the number of gene fusions was associated with the prognosis of PCa. However, as the quantitative correlations were only moderately strong, further validation and assessment of clinical value is required before potential application.

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关键词

Biomarker, Gene fusion, Genomic instability, Molecular diagnostic testing, Molecular pathology, Next-generation sequencing, Prognosis, Prostate cancer, Transcriptome

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