Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3 , Dra , and Sglt1 contribute to diarrhea during Clostridioides difficile infection.

F Christopher Peritore-Galve,Izumi Kaji,Anna Smith,Lauren M Walker,John A Shupe,M Kay Washington,Holly M Scott Algood,Pradeep K Dudeja,James R Goldenring,D Borden Lacy

Gut microbes（2023）

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摘要

CDI increases intestinal permeability and decreases apical abundance of NHE3, SGLT1, and DRA. This combination likely leads to dysfunctional water and solute absorption in the large bowel, causing osmotic diarrhea. These findings provide insights into the pathophysiological mechanisms underlying diarrhea and may open novel avenues for attenuating CDI-associated diarrhea.

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关键词

intestinal permeability,absorptive downregulation transporters,diarrhea,infection

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