Chemical Composition and Acetylcholinesterase Inhibitory Activity of Essential Oil from the Leaves of Mitrephora Poilanei Weeras. & R.M.K. Saunders

The present study provides the first information on the chemical composition and acetylcholinesterase inhibitory activity of the essential oil (EO) from the leaves of Mitrephora poilanei Weeras. & R.M.K.Saunders from Vietnam. Gas chromatography and gas chromatography-mass spectrometry analysis revealed that the main components of the M. poilanei EO were beta-caryophyllene (13.2%), a-humulene (10.5%), germacrene D (8.1%), beta-elemene (5.2%) and bicyclogermacrene (5.1%). The anti-acetylcholinesterase assay showed that the EO displayed moderate activity with IC50 value of 31.16 +/- 3.06 mu g/mL. These findings proposed that the plant can be exploited for its anti-acetylcholinestrate potential.