Antagonic effect of ghrelin and LEAP-2 on hepatic stellate cell activation and liver fibrosis in obesity-associated NAFLD.

Silvia Ezquerro,Carlota Tuero,Sara Becerril,Víctor Valentí,Rafael Moncada,Manuel F Landecho,Victoria Catalán,Javier Gómez-Ambrosi,Fátima Mocha,Camilo Silva,Karen Piper Hanley,Javier Escalada,Gema Frühbeck,Amaia Rodríguez

European journal of endocrinology（2023）

引用 0|浏览5

暂无评分

摘要

Ghrelin is an anti-fibrogenic factor blocking HSC activation induced by the most potent fibrogenic cytokine, TGF-β1, and LEAP-2. The imbalance between acylated ghrelin and ghrelin receptor antagonist LEAP-2 might contribute to maintain liver fibrosis in patients with obesity and NAFLD.

查看译文

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要