Ethanol inhibition of undifferentiated rat neural progenitor cell replication can be prevented by chlorogenic acid via the NFATc4/CSE signalling pathway.

Sambantham Shanmugam,Dhyanesh Patel, Angelica L Rodriguez, Aashlesha Walchale, Xiaobo Liu,Susan E Bergeson,Lenin Mahimainathan,Madhusudhanan Narasimhan,George I Henderson

Alcohol (Hanover, York County, Pa.)（2023）

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摘要

These findings demonstrate that EtOH can perturb CSE-dependent redox homeostasis via impairing the NFATc4 signalling pathway in neuroblasts. Notably, EtOH-associated impairments were rescued by genetic or pharmacological activation of NFATc4. Further, we report a potential role for CGA in mitigating the EtOH-related neuroblast toxicity with a compelling connection to the NFATc4/CSE pathway.

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关键词

alcohol, FASD, neural progenitor cells, oxidative stress, transsulfuration pathway

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