Impact of cytoreduction and remission status on hematopoietic cell transplantation outcomes in pediatric myelodysplastic syndrome and related disorders.

Franziska Wachter,Kyle Hebert,Yana Pikman,Jiemin Yang, Binita Shah,Jacob Bledsoe,Akiko Shimamura,Donna S Neuberg,Jessica A Pollard,Leslie E Lehmann

Pediatric blood & cancer（2023）

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摘要

Cytoreduction did not provide survival benefit in our overall cohort, but its increased use in children with higher risk disease impacted the analysis. Patients receiving cytoreduction and achieving MRD-negative status before HCT demonstrated improved OS compared to those with persistent disease.

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关键词

disease control, hematopoietic cell transplantation, myelodysplastic syndromes, pre-transplant cytoreduction

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