Association of Neighborhood Deprivation with White Matter Connectome Abnormalities in Temporal Lobe Epilepsy.

Our findings demonstrate: 1) the general impact of TLE on DWI connectome status is larger than the association with neighborhood disadvantage; however, 2) neighborhood disadvantage, indexed by ADI, revealed modest relationships to white matter structure and integrity on sensitivity analysis in TLE. Further studies are needed to explore this relationship and determine if the white matter relationship with ADI is driven by social drift or environmental influences on brain development. Understanding the etiology and course of the disadvantage-brain integrity relationship may serve to inform care, management, and policy for patients.