USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.

Jianjun Li,Xuechun Xiao,Yang Ou,Lixia Cao, Min Guo,Chunchun Qi,Zhaoyang Wang,Yuxin Liu,Qiuying Shuai,Hang Wang,Peiqing Sun,Yi Shi,Guang Yang,Shuang Yang

Cancer communications (London, England)（2023）

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摘要

Together, our results demonstrated that the USP51/PD-L1/ITGB1 network potentially contributes to the malignant progression and therapeutic resistance in NSCLC. This knowledge is beneficial to the future design of advanced cancer therapy.

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关键词

chemosensitivity,dihydromyricetin,immune‐independence,ITGB1,non‐small cell lung cancer,PD‐L1

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