Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis.

Henrique Inhauser Riceti Magalhães,Felipe Alexandre Machado,Roberta Figueiroa Souza,Marcos Antônio Ferreira Caetano,Vanessa Ribeiro Figliuolo,Robson Coutinho-Silva,Patricia Castelucci

World journal of gastroenterology（2023）

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摘要

Ulcerative colitis affects myenteric neurons in WT mice but has a weaker effect in P2X7 receptor KO mice, and neuronal death may be associated with P2X7 receptor-mediated caspase-3 activation. The P2X7 receptor can be a therapeutic target for IBDs.

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关键词

Cell death, Enteric nervous system, Gastroenterology, Inflammatory bowel diseases, Purinergic signaling

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