Potential biomarkers uncovered by bioinformatics analysis in sotorasib resistant-pancreatic ductal adenocarcinoma.

Prasanna Srinivasan Ramalingam,Annadurai Priyadharshini,Isaac Arnold Emerson,Sivakumar Arumugam

Frontiers in medicine（2023）

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摘要

Finally, we conclude that RPS3 is a crucial biomarker in sotorasib resistance which evades apoptosis by MDM2/4 interaction. We also suggest that the combinatorial treatment of sotorasib and RNA polymerase I machinery inhibitors could be a possible strategy to overcome resistance and should be studied in and settings in near future.

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关键词

sotorasib, KRAS G12C inhibitor, resistance, pancreatic ductal adenocarcinoma, ribosomal proteins, precision medicine

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