Study on the material basis and action mechanisms of sophora davidii (Franch.) skeels flower extract in the treatment of non-small cell lung cancer.

Baibai Ye,Ping Chen,Cheng Lin,Chenning Zhang,Linfu Li

Journal of ethnopharmacology（2023）

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摘要

The combination of network pharmacology, molecular docking, database validation, and in vitro experimental validation effectively demonstrates that SDFE can promote cell apoptosis by regulating PI3K-AKT/MDM2-P53 signaling pathway, so as to treat NSCLC.

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关键词

Sophora davidii (Franch, ) skeels flower, UHPLC-Q-exactive-orbitrap-MS, MS, Network pharmacology, PI3K-AKT, MDM2-P53

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