Localization of EGFR Mutations in Non-small-cell Lung Cancer Tissues Using Mutation-specific PNA-DNA Probes.

Hajime Shigeto,Haruo Miyata,Tadashi Ashizawa,Akira Iizuka,Yasufumi Kikuchi,Chikako Hozumi,Chie Maeda,Ken Yamaguchi,Shohei Yamamura,Yasuto Akiyama

Cancer genomics & proteomics（2023）

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摘要

PNA-DNA probes specific for EGFR mutations might be useful tools to detect heterogeneous mutant EGFR expression in cancer tissues and efficiently evaluate the effect of EGFR signaling inhibitors on tissues of EGFR-mutant cancer.

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关键词

PNA-DNA probe, EGFR mutation, tumor heterogeneity, multicolor immunofluorescence, image analysis software

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