Hypoxia-stabilized RIPK1 promotes cell death
Nature cell biology（2023）
摘要
The PHD–pVHL pathway is essential for oxygen-dependent prolyl hydroxylation of HIFA. A recent study identifies RIPK1 as a hydroxylation target in this pathway during hypoxia-induced cell death and presents a 2.8 Å resolution crystal structure of the pVHL–elongin B/C complex bound to hydroxylated RIPK1.
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关键词
Inflammation,Necroptosis,Post-translational modifications,Stress signalling,Life Sciences,general,Cell Biology,Cancer Research,Developmental Biology,Stem Cells
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