Mitochondrial aspartate/glutamate carrier AGC1 regulates cardiac function via Drp1-mediated mitochondrial fission in doxorubicin-induced cardiomyopathy.

Yan Xia,Jiayu Jin,Ao Chen,Danbo Lu,Xinyu Che,Jiaqi Ma,Su Li,Ming Yin,Zheng Yang,Hao Lu,Chenguang Li,Jinxiang Chen,Muyin Liu,Yuan Wu,Hui Gong,Yunzeng Zou,Zhangwei Chen,Juying Qian,Junbo Ge

Translational research : the journal of laboratory and clinical medicine（2023）

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摘要

In summary, our data illustrate that AGC1, as a novel contributor to DCM, regulates cardiac function via Drp1-mediated mitochondrial fission, indicating that targeting AGC1-Drp1 axis could be a potential therapeutic strategy for DOX-induced cardiomyopathy.

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关键词

mitochondrial aspartate/glutamate,aspartate/glutamate carrier agc1,cardiac function,mitochondrial fission,doxorubicin-induced

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