Insulin-like growth factor 1 supplementation supports motor coordination and affects myelination in preterm pigs.

Line I Christiansen, Gemma C Ventura,Bo Holmqvist,Karoline Aasmul-Olsen, Sandy E H Lindholm,Matthew D Lycas,Yuki Mori,Jan Bojsen-Møller Secher,Douglas G Burrin,Thomas Thymann,Per T Sangild,Stanislava Pankratova

Frontiers in neuroscience（2023）

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摘要

Supplemental IGF-1 during the first three weeks after preterm birth may support motor function by enhancing GABAergic maturation in the caudate nucleus, despite reduced myelination. Supplemental IGF-1 may support postnatal brain development in preterm infants, but more studies are required to identify optimal treatment regimens for subgroups of very or extremely preterm infants.

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关键词

myelination,preterm pigs,motor coordination,insulin-like

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