Mediation analysis of the testosterone treatment effect to prevent type 2 diabetes in the T4DM trial.

Kristy P Robledo,Ian C Marschner,David J Handelsman,Karen Bracken,Bronwyn G A Stuckey,Bu B Yeap,Warrick Inder,Mathis Grossmann,David Jesudason,Carolyn A Allan,Gary Wittert

European journal of endocrinology（2023）

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摘要

At least part of the testosterone treatment effect was found to be mediated by changes in fat mass, abdominal fat, skeletal muscle mass, grip strength, SHBG, and E2, but predominantly by changes in fat mass.

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