Enzymatic activity of 38 CYP2C9 genotypes on ibuprofen.

Ling-Jing Yuan,Xiang-Yu Li,Feng Ye,Xin-Yue Li,Qing-Qing Li,Yun-Shan Zhong, Shi-Yu Wang,Ya-Hui Wang,Guo-Xin Hu,Jian-Ping Cai,Jun-Wei Li

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association（2023）

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摘要

This is the first systematic evaluation of the catalytic characteristics of 38 CYP2C9 genotypes involved ibuprofen metabolism. Our results provide a corresponding supplement to studies on CYP2C9 gene polymorphisms and kinetic characteristics of different variants. We need to focus on poor metabolizers (PMs) with severely abnormal metabolic functions, because they are more susceptible to drug exposure.

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关键词

CYP2C9,Variants,Gene polymorphism,Ibuprofen

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