Physical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort.

Leslie Grasset,Vincent Planche,Vincent Bouteloup,Chabha Azouani,Bruno Dubois,Frédéric Blanc,Claire Paquet,Renaud David,Catherine Belin,Thérèse Jonveaux,Adrien Julian,Jérémie Pariente,Jean-François Mangin,Geneviève Chêne,Carole Dufouil

Alzheimer's & dementia : the journal of the Alzheimer's Association（2023）

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摘要

Physical activity is an interesting modifiable target for dementia prevention. Physical activity may moderate the impact of brain pathology on dementia risk. Medial temporal lobe atrophy and plasma amyloid beta 42/40 ratio were associated with increased dementia risk especially in those with low level of physical activity.

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brain changes, cognitive reserve, dementia, physical activity

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