Effects of Striatal Amyloidosis on the Dopaminergic System and Behavior: A Comparative Study in Male and Female 5XFAD Mice.

Theresa A Lansdell,Hui Xu,James J Galligan,Anne M Dorrance

Journal of Alzheimer's disease : JAD（2023）

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摘要

Our results indicate that the progression of amyloidosis involves the striatum in females to a greater extent than in males. These studies have significant implications for using male-only cohorts in the study of AD progression.

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关键词

Alzheimer's disease, amyloid-beta, dopamine neurotransmission, hyperlocomotion, 5XFAD

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