Transcriptomic identification of genes expressed in invasive S. aureus diabetic foot ulcer infection.

An increased expression of , , , , and was noted during active infection at 0 weeks compared with that at 8 weeks. Lysine- and arginine-rich histones (, , , , and ) were upregulated at the initial phase of active infection at 0 weeks. and were also upregulated at the initial phase of active infection (0 weeks) compared with that at 8 weeks of follow-up. Genes of heat shock protein members (, , and ) were high in not healed patients compared with that in healed patients 8 weeks after therapy. The outcome of our study suggests that the identification of genes evolution based on a transcriptomic profiling could be a useful tool for diagnosing infection and assessing severity and host immune response to therapies.