Pd14-08 phenotyping oab patients with urologic or non-urologic pain – and comparison to oab patients without pain, findings from the lurn study

You have accessJournal of UrologyCME1 Apr 2023PD14-08 PHENOTYPING OAB PATIENTS WITH UROLOGIC OR NON-UROLOGIC PAIN – AND COMPARISON TO OAB PATIENTS WITHOUT PAIN, FINDINGS FROM THE LURN STUDY H Henry Lai, Margaret Helmuth, Abigail Smith, Claire Yang, Kimberly Kenton, Carol Bretschneider, Anne Cameron, J. Quentin Clemens, Catherine Bradley, Amie Kawasaki, Ziya Kirkali, and Steven Harte H Henry LaiH Henry Lai More articles by this author , Margaret HelmuthMargaret Helmuth More articles by this author , Abigail SmithAbigail Smith More articles by this author , Claire YangClaire Yang More articles by this author , Kimberly KentonKimberly Kenton More articles by this author , Carol BretschneiderCarol Bretschneider More articles by this author , Anne CameronAnne Cameron More articles by this author , J. Quentin ClemensJ. Quentin Clemens More articles by this author , Catherine BradleyCatherine Bradley More articles by this author , Amie KawasakiAmie Kawasaki More articles by this author , Ziya KirkaliZiya Kirkali More articles by this author , and Steven HarteSteven Harte More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003261.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Some patients with OAB experience pain in addition to urinary urgency (UU) and/or urgency incontinence (UUI). Lai et al (2014) showed that 33% of OAB patients reported pain in the bladder, and hypothesized that OAB with pain resemble OAB-dry without UUI. Reynolds et al (2017) reported even higher rates of concomitant urologic pain in OAB patients, and hypothesized that OAB patients with pain may have central sensitization. The objectives of this study are to further phenotype OAB patients with urologic and non-urologic pain and to compare to those without pain. METHODS: Care-seeking adult women and men with OAB (UU with or without UUI) who enrolled in the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Neuroimaging and Sensory Testing Study completed questionnaires assessing their urologic pain (LURN SI-29 pain subscale), non-urologic pain (Brief Pain Inventory), OAB symptoms, urinary incontinence, psychosocial measures (anxiety, depression, stress levels, trauma), and generalized sensitivity scales (GSS sensory sensitivity, GSS somatic awareness). RESULTS: Among the 191 OAB participants, 68% reported urologic pain (bladder pain, dysuria), with median pain ratings of 6 out of 100 (interquartile range, IQR 0-25) on the LURN SI-29 pain subscale. 57% reported non-urologic pain, with median pain severity of 1.4 out of 10 (IQR 0-3) on the Brief Pain Inventory. OAB patients with urologic pain had more severe OAB symptoms, psychosocial issues (depression, anxiety, stress) and higher GSS scores than OAB without urologic pain; however, there were no differences in urinary incontinence measures. OAB with non-urologic pain had more severe OAB symptoms, urinary incontinence, psychosocial issues (depression, anxiety, stress) and higher GSS scores than OAB without non-urologic pain (see Figure 1). CONCLUSIONS: In care seeking patients with LUTS, nearly 2/3 of patients with OAB report mild urologic or non-urologic pain. OAB and urinary incontinence symptoms are more severe in those with pain. Our data supports the concept that the OAB with pain phenotype may have heightened sensitivity and/or awareness to bodily sensation such as urinary urgency and pain. OAB patients reporting concomitant pain appears to represent a separate subgroup of OAB. Source of Funding: NIH/NIDDK © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e415 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information H Henry Lai More articles by this author Margaret Helmuth More articles by this author Abigail Smith More articles by this author Claire Yang More articles by this author Kimberly Kenton More articles by this author Carol Bretschneider More articles by this author Anne Cameron More articles by this author J. Quentin Clemens More articles by this author Catherine Bradley More articles by this author Amie Kawasaki More articles by this author Ziya Kirkali More articles by this author Steven Harte More articles by this author Expand All Advertisement PDF downloadLoading ...