LEAP2 is Associated with Cardiometabolic Markers, but is Unchanged by Antidiabetic Treatment in People with Prediabetes.
American journal of physiology. Endocrinology and metabolism(2023)
摘要
Aims To examine whether fasting plasma liver-expressed antimicrobial peptide 2 (FP-LEAP2) is associated with markers of cardiometabolic disease susceptibility in a cohort with prediabetes and overweight/obesity and whether antidiabetic interventions affect FP-LEAP2 levels. Materials and methods The analysis included 115 individuals with prediabetes (hemoglobin A (HbA) 39-47 mmol/mol, 5.7-6.4%) and overweight/obesity (BMI ≥ 25 kg/m) from a randomized controlled trial. Changes in FP-LEAP2 levels were assessed in relation to treatment with dapagliflozin (10 mg once daily), metformin (1700 mg daily) or interval-based exercise (5 days/week, 30 min/session) compared to control (habitual lifestyle) after 6 and 13 weeks of treatment. Results FP-LEAP2 levels were associated with (standardized beta-coefficient (95%-CI)): BMI 0.22 (0.03:0.41), p=0.027; body weight 0.27 (0.06:0.48), p=0.013; fat mass 0.2 (0.00:0.4), p=0.048; lean mass 0.47 (0.13:0.8), p=0.008; HbA 0.35 (0.17:0.53), p<0.001; fasting plasma glucose (FPG) 0.32 (0.12:0.51), p=0.001; fasting serum insulin 0.28 (0.09:0.47), p=0.005; insulin sensitivity -0.22 (-0.41:-0.03), p=0.022; total cholesterol 0.19 (0.01:0.38), p=0.043; triglycerides: 0.31 (0.13:0.5), p<0.001; transaminases and Fatty Liver Index (standardized beta-coefficients 0.23-0.32), all p<0.020; and eGFR -0.34 (-0.56:-0.12), p=0.003. FP-LEAP2 levels were not associated with fat distribution or body fat percentage, fasting glucagon, post-load glucose, beta cell function or low-density lipoprotein. The interventions were not associated with changes in FP-LEAP2. Conclusion FP-LEAP2 is associated with body mass, impaired insulin sensitivity, liver specific enzymes and kidney function. The findings highlight the importance of LEAP2 in obesity, type 2 diabetes, and non-alcoholic fatty liver disease. FP-LEAP2 was not affected by metformin, dapaglifloxin, or exercise in this population.
更多查看译文
关键词
antidiabetic interventions, cardiometabolic risk, LEAP2, obesity, prediabetes
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要