Association of Molecular Profiles and Mutational Status With Distinct Histological Lung Adenocarcinoma Subtypes. An Analysis of the LACE-Bio Data.

Prashanth Ashok Kumar,Maryam Karimi,Alina Basnet,Lesley Seymour,Robert Kratzke,Elizabeth Brambilla,Thierry Le-Chevalier,Jean-Charles Soria,Ken André Olaussen,Siddhartha Devarakonda,Ramaswamy Govindan,Ming-Sound Tsao,Frances A Shepherd,Stefan Michiels,Stephen Graziano

Clinical lung cancer（2023）

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摘要

High TMB has a prognostic role in resectable lung ADC. The high TMB group had a poor outcome with AC, suggesting that this group may be better served with immune checkpoint therapy.

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关键词

Non-small cell lung cancer (NSCLC),Lung adjuvant cisplatin evaluation (LACE),PD-L1,Tumor mutational burden (TMB),Tumor infiltrating lymphocytes (TIL)

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