Antioxidative Impact of Phenolics-Loaded Nanocarriers on Cytoskeletal Network Remodeling of Invasive Cancer Cells

Natural phenolic compounds have antioxidant propertiesowing totheir free radical-scavenging capability. The combined effect of amixture of phenolic compounds has been studied; however, the detailedinvestigation for finding a correlation between single phenolic moleculesand antioxidant activity has not been explored. Herein, we revealedthat the number of phenolic hydroxyl groups in phenolics played acentral role in their antioxidant capacity. Based on the finding,tannic acid showed the most effective antioxidant potential, e.g.,76% in tannic acid versus 22% in vitamin C as a standard antioxidantcomponent. Because cancer progression is closely related to oxidativeprocesses at the cellular level, we further applied the surface treatmentof tannic acid drug-delivery nanocarriers. Tannic acid-loaded nanocarriersreduced reactive oxygen species of cancer cells as much as 41% ofvehicle treatment and remodeled cytoskeletal network. By a gelatindegradation study, TA-loaded nanocarrier-treated cells induced 44.6%reduction of degraded area than vehicle-treated cells, implying apotential of blocking invasiveness of cancer cells.