Diagnostic challenge in a case of ambiguous lineage acute leukemia with PICALM::MLLT10 rearrangement.

Pediatric blood & cancer(2023)

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Pediatric Blood & CancerEarly View e30573 LETTER TO THE EDITOR Diagnostic challenge in a case of ambiguous lineage acute leukemia with PICALM::MLLT10 rearrangement Julie Quessada, Julie Quessada Département d'Hématologie, APHM, Hôpital La Timone, Marseille, France CRCM, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes, Marseille, FranceSearch for more papers by this authorAudrey Petit, Audrey Petit Département d'Hématologie et d'Oncologie Pédiatrique, APHM, Hôpital La Timone, Marseille, FranceSearch for more papers by this authorPaul Saultier, Paul Saultier Département d'Hématologie et d'Oncologie Pédiatrique, APHM, Hôpital La Timone, Marseille, France Aix Marseille Université, INSERM, INRA, C2VN, Marseille, FranceSearch for more papers by this authorLaurène Fenwarth, Laurène Fenwarth orcid.org/0000-0003-2808-4843 Laboratoire Hématologie, Centre de Biologie Pathologie Génétique, CHU Lille, Lille, France U1277 Cancer Heterogeneity Plasticity and Resistance to Therapies (CANTHER), University of Lille, INSERM, Lille, FranceSearch for more papers by this authorAlice Marceau-Renaut, Alice Marceau-Renaut Laboratoire Hématologie, Centre de Biologie Pathologie Génétique, CHU Lille, Lille, France U1277 Cancer Heterogeneity Plasticity and Resistance to Therapies (CANTHER), University of Lille, INSERM, Lille, FranceSearch for more papers by this authorIsabelle Arnoux, Isabelle Arnoux Département d'Hématologie, APHM, Hôpital La Timone, Marseille, FranceSearch for more papers by this authorDominique Payet-Bornet, Dominique Payet-Bornet CRCM, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes, Marseille, FranceSearch for more papers by this authorGérard Michel, Gérard Michel Département d'Hématologie et d'Oncologie Pédiatrique, APHM, Hôpital La Timone, Marseille, FranceSearch for more papers by this authorMarina Lafage, Marina Lafage Département d'Hématologie, APHM, Hôpital La Timone, Marseille, FranceSearch for more papers by this authorMarie Loosveld, Corresponding Author Marie Loosveld [email protected] orcid.org/0000-0002-8372-4148 Département d'Hématologie, APHM, Hôpital La Timone, Marseille, France CRCM, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes, Marseille, France Correspondence Marie Loosveld, Department of Hematology Biology, La Timone Hospital, 264 rue Saint Pierre, 13005, Marseille, France. Email: [email protected]Search for more papers by this author Julie Quessada, Julie Quessada Département d'Hématologie, APHM, Hôpital La Timone, Marseille, France CRCM, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes, Marseille, FranceSearch for more papers by this authorAudrey Petit, Audrey Petit Département d'Hématologie et d'Oncologie Pédiatrique, APHM, Hôpital La Timone, Marseille, FranceSearch for more papers by this authorPaul Saultier, Paul Saultier Département d'Hématologie et d'Oncologie Pédiatrique, APHM, Hôpital La Timone, Marseille, France Aix Marseille Université, INSERM, INRA, C2VN, Marseille, FranceSearch for more papers by this authorLaurène Fenwarth, Laurène Fenwarth orcid.org/0000-0003-2808-4843 Laboratoire Hématologie, Centre de Biologie Pathologie Génétique, CHU Lille, Lille, France U1277 Cancer Heterogeneity Plasticity and Resistance to Therapies (CANTHER), University of Lille, INSERM, Lille, FranceSearch for more papers by this authorAlice Marceau-Renaut, Alice Marceau-Renaut Laboratoire Hématologie, Centre de Biologie Pathologie Génétique, CHU Lille, Lille, France U1277 Cancer Heterogeneity Plasticity and Resistance to Therapies (CANTHER), University of Lille, INSERM, Lille, FranceSearch for more papers by this authorIsabelle Arnoux, Isabelle Arnoux Département d'Hématologie, APHM, Hôpital La Timone, Marseille, FranceSearch for more papers by this authorDominique Payet-Bornet, Dominique Payet-Bornet CRCM, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes, Marseille, FranceSearch for more papers by this authorGérard Michel, Gérard Michel Département d'Hématologie et d'Oncologie Pédiatrique, APHM, Hôpital La Timone, Marseille, FranceSearch for more papers by this authorMarina Lafage, Marina Lafage Département d'Hématologie, APHM, Hôpital La Timone, Marseille, FranceSearch for more papers by this authorMarie Loosveld, Corresponding Author Marie Loosveld [email protected] orcid.org/0000-0002-8372-4148 Département d'Hématologie, APHM, Hôpital La Timone, Marseille, France CRCM, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes, Marseille, France Correspondence Marie Loosveld, Department of Hematology Biology, La Timone Hospital, 264 rue Saint Pierre, 13005, Marseille, France. Email: [email protected]Search for more papers by this author First published: 13 July 2023 https://doi.org/10.1002/pbc.30573Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Patel SS, Weinberg OK. Diagnostic workup of acute leukemias of ambiguous lineage. Am J Hematol. 2020; 95(6): 718-722. 10.1002/ajh.25771 2Khoury JD, Solary E, Abla O, et al. The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms. Leukemia. 2022; 36(7): 1703-1719. 10.1038/s41375-022-01613-1 3Alexander TB, Gu Z, Iacobucci I, et al. The genetic basis and cell of origin of mixed phenotype acute leukaemia. Nature. 2018; 562(7727): 373-379. 10.1038/s41586-018-0436-0 4Lee HG, Baek HJ, Kim HS, Park SM, Hwang TJ, Kook H. Biphenotypic acute leukemia or acute leukemia of ambiguous lineage in childhood: clinical characteristics and outcome. Blood Res. 2019; 54(1): 63-73. 10.5045/br.2019.54.1.63 5Bohlander S, Muschinsky V, Schrader K, et al. Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients. Leukemia. 2000; 14(1): 93-99. 10.1038/sj.leu.2401614 6Dreyling MH, Martinez-Climent JA, Zheng M, Mao J, Rowley JD, Bohlander SK. The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. Proc Natl Acad Sci U S A. 1996; 93(10): 4804-4809. 7Forgione MO, McClure BJ, Yeung DT, Eadie LN, White DL. MLLT10 rearranged acute leukemia: incidence, prognosis, and possible therapeutic strategies. Genes Chromosom Cancer. 2020; 59(12):709-721. doi:10.1002/gcc.22887 8Girardi T, Vicente C, Cools J, De Keersmaecker K. The genetics and molecular biology of T-ALL. Blood. 2017; 129(9): 1113-1123. 10.1182/blood-2016-10-706465 9Hrusak O, de Haas V, Stancikova J, et al. International cooperative study identifies treatment strategy in childhood ambiguous lineage leukemia. Blood. 2018; 132(3): 264-276. 10.1182/blood-2017-12-821363 10Orgel E, Alexander TB, Wood BL, et al. Mixed phenotype acute leukemia: a cohort and consensus research strategy from the Children's Oncology Group Acute Leukemia of Ambiguous Lineage Task Force. Cancer. 2020; 126(3): 593-601. 10.1002/cncr.32552 11Asnafi V, Radford-Weiss I, Dastugue N, et al. CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRgammadelta lineage. Blood. 2003; 102(3): 1000-1006. 10.1182/blood-2002-09-2913 12Montefiori LE, Mullighan CG. Redefining the biological basis of lineage-ambiguous leukemia through genomics: BCL11B deregulation in acute leukemias of ambiguous lineage. Best Pract Res Clin Haematol. 2021; 34(4):101329. 10.1016/j.beha.2021.101329 Early ViewOnline Version of Record before inclusion in an issuee30573 ReferencesRelatedInformation
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ambiguous lineage acute leukemia,acute leukemia,ambiguous lineage,diagnostic challenge
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